Medically reviewed article

Treatment with anti-nausea medication

Anti-nausea medication can be taken during migraine attacks if you experience severe nausea or vomiting. Some patients suffer from intense nausea and vomiting as part of their migraine attacks. In some cases, it is so severe that it is difficult to take migraine treatment. In such instances, it may be an option to take anti-nausea medication either 20 minutes before or at the same time as your migraine medication. There are several options, which you can read about below.

By
Hemi Health
Hemi Health

Metoclopramide

Metoclopramide works by accelerating the emptying of the stomach and the motility of the entire intestinal tract. It also affects receptors in the brain that suppress nausea and vomiting.

Common side effects include drowsiness and diarrhea.

If you have not had an electrocardiogram (ECG) within the last 2 years, you must have one taken before starting treatment.

Metoclopramide tablets are 10 mg; you may take a maximum of 3 tablets per day.

Domperidone

Domperidone works by accelerating the emptying of the stomach and the motility of the entire intestinal tract.

Common side effects include dry mouth and diarrhea.

If you have not had an electrocardiogram (ECG) within the last 2 years, you must have one taken before starting treatment.

Domperidone tablets are 10 mg; you may take a maximum of 3 tablets per day.

Domperidone is also available as suppositories. They are 30 mg, must be prepared at the pharmacy, and are therefore relatively expensive. You may take a maximum of 1 suppository per day.

Ondansetron

Ondansetron works by blocking the vomiting reflex both in the body and in the brain.

Common side effects include headache and constipation.

If you have not had an electrocardiogram (ECG) within the last 2 years, you must have one taken before starting treatment.

Ondansetron tablets are 4 mg or 8 mg; you may take a maximum of 2 tablets per day.

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