Preventive treatment with Rimegepant, also known as Vydura

The product

Vydura is developed specifically for the treatment of migraines. Vydura can be used as acute treatment but is also approved for the prevention of migraines in adults with episodic migraine who have at least 4 migraine attacks per month.

Vydura is not believed to cause medication-overuse headache and can therefore be used as acute treatment beyond the 9 recommended days for, e.g., triptans or other painkillers.

Mechanism of action

It is known that CGRP (calcitonin gene-related peptide), which is produced in our nervous system, plays an active role in a migraine attack.

Rimegepant, the active ingredient in Vydura, is believed to work by binding specifically to the CGRP molecule's receptor, thereby preventing the transmission of pain signals to the brain. This may reduce the number and severity of your migraine attacks.

Vydura has a half-life of approximately 11 hours, which means it is cleared from the body after a few days.

Side effects

Approximately 1-10% experience nausea. Very rarely (approx. 0.1%), rash and difficulty breathing are observed.

If you experience side effects not mentioned here, please let us know so we can report them to the Danish Medicines Agency.

Precautions

Vydura must not be used by pregnant or breastfeeding women.

You must stop taking Vydura at least 5 days before trying to conceive.

Vydura should not be used in combination with certain specific medications.

What is the recommended dosage?

Acute treatment: You should take 1 tablet of 75 mg as early in the attack as possible. You must not take more than 1 tablet of Vydura per day.

Preventive: You should take 1 tablet of 75 mg every other day. If you have a migraine attack on a day when you have already taken Vydura either as preventive or acute treatment, you may use another acute treatment, such as a triptan.

How should Vydura be taken?

Place the tablet under the tongue, where it will dissolve and be swallowed with saliva. You should not drink or eat for at least 5 minutes after administration.

Subsidies

Conditional reimbursement is provided for Vydura as acute treatment if the following criteria are met:
You must be receiving relevant preventive treatment.

Furthermore, you must have tried at least three different triptans, either without effect or with unacceptable side effects, OR have a contraindication for triptans, including having more than 9 attacks requiring treatment per month.

Subsidies are provided for a maximum of 8 tablets per month.